Tirzepatide, a dual GIPR/GLP-1R agonist approved for T2D and obesity, has shown preclinical neurobiological effects consistent with neuroprotection in models of diabetic neurodegeneration, Alzheimer-type amyloidosis, and Parkinsons disease
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it also helps in generating heat and boosting mood through the release of endorphins
Proteins are also involved in stimulating CCK release via inhibition of trypsin-mediated digestion of intestinal CCK releasing peptides.52 This effect has been shown to be significant especially after ingestion of liquid whey, but also after casein, soy and gluten or after a whey protein meal
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Research focuses on its role in sleep regulation, stress adaptation, and pain modulation through complex interactions with the hypothalamic-pituitary system
