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While currently approved GLP-1 and GIP/GLP-1 RAs have multiple on-label indications, many of them are also used off-label
Retatrutide is a triple agonist that adds glucagon receptor activity to the GLP-1/GIP profile
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approved for cardiovascular risk reduction a major expansion beyond its initial 2019 approval for glucose control
The biggest difference is that semaglutide is not a stimulant
True gynaecomastia involves glandular breast tissue growth driven by an oestrogen-androgen imbalance, not simply fat accumulation in the chest
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