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noted that the research on body losses is relatively old, inconsistent, and it might not be further clarified due to the ethical concerns with using radioisotopes for tracking B12 in the body

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Younger researchers are adding to existing levels

Under constant exposure, receptors are pulled off the cell surface and become less responsive over time (receptor desensitization). Higher doses maintain more signal against that fade

GO and KEGG pathway enrichment analysis GO analysis was performed to elucidate the biological functions of the potential targets (Fig