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Most patients can safely increase from their current dose in 0.250.5 mg increments weekly or every other week

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The troubleshooting guide for semaglutide notes that overdosing paradoxically can stall weight loss due to the body stress response and inability to maintain adequate nutrition

iScience 26:105717 Kriston L, von Wolff A, Westphal A, Holzel LP, Harter M (2014) Efficacy and acceptability of acute treatments for persistent depressive disorder: a network meta-analysis

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What makes GLP-1 drugs particularly intriguing is that they appear to work through a mechanism distinct from traditional addiction treatments