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Concurrently, pro-inflammatory cytokines regulate the activity of key enzymes in tryptophan metabolismindoleamine IDO and TDOpromoting the production of kynurenine pathway metabolites such as KYNA

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The substantia nigra isnt traditionally considered a primary serotonergic center (that distinction belongs to raphe nuclei), yet BPC-157s consistent elevation of serotonin there suggests a unique therapeutic approach