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During oxidative phosphorylation, mitochondria generate and scavenge reactive oxygen species (ROS)
Our team has also shown increased GLP-1 RA prescribing (Gratzl et al., 2024)
K.Cruz-GregorioA.Pedraza-ChaverriJ
Once someone has done all the right things for nutrition, fitness, sleep, stress management, and frailty prevention, then having a conversation about adding a pharmacologic option for longevity or optimization becomes appropriate. The Takeaway GLP-1 medications, like semaglutide and tirzepatide, were originally developed for diabetes, but researchers are now exploring if they may extend lifespan and help people maintain good health for a longer period of time
Tirzepatide produced substantially greater weight loss (~78% additional) and superior glycemic control (~0.8% additional HbA1c reduction), yet the additional cardiovascular benefit over an already-active comparator was modest