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Semaglutide refers to injectable drugs prescribed for type 2 diabetes and weight loss
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This strategy has been exploited in the long-acting GLP-1RA semaglutide (Novo Nordisk), for instance, which was approved for treatment of T2DM in 2017, and for treatment of obesity in 2021, and has since then become the most prescribed GLP-1RA 92
The practical difference for most people is minimal, though methylcobalamin skips the conversion step and may be preferable for individuals with certain genetic variations affecting B12 metabolism
For example, the FDA-approved obesity dose for semaglutide is a 16-week step-up to a maintenance of 1.7 or 2.4 mg weekly
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