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both groups received lifestyle intervention, and the glycaemic-status analysis was post hoc

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10.2147/JIR.S409699 254 ThapaK.KhanH.KanojiaN.SinghT

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Semaglutide is engineered to last much longer, allowing for sustained activity and more stable metabolic effects

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2a), increased the plasma GLP-1 and insulin levels, decreased the blood glucose levels, as well as improved the oral glucose tolerance in TR flox/flox (Floxed) mice (Fig

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While initial research focused on GIPR agonism to enhance insulin secretion, genetic studies demonstrating that individuals with loss-of-function GIPR variants exhibit favorable metabolic phenotypesincluding reduced body weight and improved insulin sensitivityhave substantiated the therapeutic potential of GIPR antagonism [9, 10]

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