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Notably, the proportion stopping treatment because of side effects (7%) was barely above placebo (6%) closer than usual for this class

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It also has a broader binding affinity, affecting other melanocortin receptors beyond just the MC1R responsible for skin pigmentation

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Interestingly, the same study found that, in rats, tirzepatide suppressed lipid intake without affecting sucrose (carbohydrate) consumption in a choice-based assay, implying that the effects of these medications may be macronutrient specific (Geisler et al., 2023)

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Lancet 375:22232233 Fadini GP, Avogaro A (2017) SGTL2 inhibitors and amputations in the US FDA adverse event reporting system

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Original Medicare does not cover routine dental care, but many Medicare Advantage plans include preventive dental benefits

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