Notably, the proportion stopping treatment because of side effects (7%) was barely above placebo (6%) closer than usual for this class
It also has a broader binding affinity, affecting other melanocortin receptors beyond just the MC1R responsible for skin pigmentation
Interestingly, the same study found that, in rats, tirzepatide suppressed lipid intake without affecting sucrose (carbohydrate) consumption in a choice-based assay, implying that the effects of these medications may be macronutrient specific (Geisler et al., 2023)
Thompson A, Maibach HI
Lancet 375:22232233 Fadini GP, Avogaro A (2017) SGTL2 inhibitors and amputations in the US FDA adverse event reporting system
Original Medicare does not cover routine dental care, but many Medicare Advantage plans include preventive dental benefits