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A separate 2025 narrative review confirmed three total published human pilot studies and noted that no major adverse events were reported across those pilots [15]

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[13] Causality clue (mechanisms): NIH inpatient RCT (calories/macros/fibre matched): UPF diet led to ~+500 kcal/day intake and +0.9 kg in 2 weeks vs unprocessedimplicates palatability, eating rate, energy density, and structure , not just nutrients

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