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Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, bloodbrain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion
Natural polysaccharides may have many potential antidiabetic activities waiting for us to explore
Tirzepatide (Mounjaro, Zepbound) Strengths: Highest efficacy for both glucose control and weight loss Dual mechanism (GLP-1 + GIP) may provide unique benefits Once-weekly dosing Generally well-tolerated Considerations: Higher cost than semaglutide Less long-term safety data (newer medication) Cardiovascular outcome trial not yet complete (though expected to be positive) Best for: Patients prioritizing maximum weight loss
The enzyme dipeptidyl peptidase 4 (DPP-IV) cleaves it between the second and third residues which renders it inactive within several minutes, and explains why GLP-1 cannot be used as a drug itself
Buckwheat, a food rich in protein and fiber, elevates GLP-1 levels that cause fullness
