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This creates a vicious, self-perpetuating cycle: mitochondrial dysfunction causes oxidative stress, and that oxidative stress causes further mitochondrial destruction

Historically, first-line systemic ADT mostly took the form of chemical castration through gonadotropin releasing hormone (GnRH) agonists and antagonists, which reduce testosterone levels by suppressing androgen secretion from the testes [4, 7, 8]

37 Combining TN with several chemotherapeutic drugs induces synergistic cell killing, indicating its efficacious antitumor effect in DLBCL and colon cancer

Analyzing The Gaps in Clinical Trial Data Some human evidence does exist

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This varies from person to person