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Lancet Child Adolesc Health 9:297305 Argente J, Verge CF, Okorie U et al (2025) Setmelanotide in patients aged 25 years with rare MC4R pathway-associated obesity (VENTURE): a 1 year, open-label, multicenter, phase 3 trial
This is why, without ongoing resistance training or other forms of mechanical load , muscle that once served to support higher body weight will naturally diminish when that weight and its mechanical demand are gone
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doi: 10.1186/s12967-024-04974-6 62 HidaM.AibaY.SawamuraS.SuzukiN.SatohT.KogaY