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And, if you live in Los Angeles (or any major metropolitan city, honestly), seemingly half of everyone you know has or is currently taking one of these medications for their weight loss-boosting effectseven if they swear their leaner frame is exclusively due to drinking more water and doing pilates. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) were initially developed and approved to treat type 2 diabetes and obesity by helping to regulate blood glucose levels, mimicking the effects of GLP-1, a naturally occurring hormone in the body that regulates digestion, appetite, and blood sugar