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In summary, FOXO4-DRI exerts its anti-aging effects by inhibiting the binding of FOXO4 to P53, promoting P53 phosphorylation, and facilitating the translocation of p-P53 from the nucleus to the cytoplasm for its functional role
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This hyper ECD motion was propagated to the receptor TMD, with motions within TMs 3 and 7, creating a wider TM pocket that also influences the positioning of the N-terminus of the Cagri peptide (Fig
World J Biol Chem 8(1):86
Notably, elevated levels of lipid peroxidation are reliably detected in brain tissues and body fluids of Alzheimers, Parkinsons, Huntingtons disease, motor neuron disease and multiple sclerosis patients ( Since its original characterisation in cancer cells, the concept of ferroptosis has instigated growing efforts to explicitly detect and measure its footprint in neurodegeneration ( in vitro
