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As a result, compared to American women, American men live an average of five years less, seek healthcare treatment half as often, and die by suicide nearly four times more often

On further time-based analysis, we demonstrated a modest reduction in weight with GLP-1 RA use within the first 3 years (2.7% of baseline body weight) before rebounding to above baseline at 5 years

Pazos MR, et al

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10.1089/dna.2009.0916 313

Phase 5: 2.4mg weekly (weeks 17 and beyond) This is the maximum FDA-approved dose for weight management, and the dose that produced the headline results in the STEP trials