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The lack of standardized methods to evaluate total antioxidant capacity and the oxidation state and the use of inadequate antioxidants and/or improper concentrations of antioxidants lead to failure of numerous clinical trials directed to prevent or mitigate progression of atherosclerosis (230233)
Consider alpha-lipoic acid (ALA) to combat oxidative stress
Neurosci Lett , 354:163165
Across corticosteroids, acetaminophen, NSAIDs, and opioids, a consistent pattern emerges: Inflammation is suppressed, but tissue repair is impaired Pain signals are blocked, but nervous system sensitivity increases Symptoms are quieted, but root causes remain unaddressed Over time, this creates a widening gap between temporary symptom relief and true physiologic recovery
We demonstrated that, although ROS are necessary for the initiation phase of ATG, the modulation of thiols are fundamental for the progression of starvation-induced ATG (Desideri et al., 2012
This study was conducted in compliance with the principles set forth in the Declaration of Helsinki
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