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In my clinic, my patients and I often uncover one or more MTHFR mutations behind their reduced detoxification

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John B Pritchard critical comments of this manuscript

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Membranes were probed using antibodies to FoxO1 (1:2500, 18592-1AP, Proteintech, Chicago, IL, USA), SOD2 (1:6000, 66474-1lg, Proteintech, Chicago, IL, USA), NOX4 (1:600, 14347-1-AP, Proteintech, Chicago, IL, USA), and -actin (1:2000, AM10218-400, Abgent) as the primary antibodies

If the body cannot detoxify with methylation pathways, glutathione detoxifies with conjugation pathways