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Ceci est particulirement important pour ceux qui ont certaines variantes enzymatiques hrditaires qui rendent le mtabolisme des folates moins efficace, puisque le 5-MTHF est dj sous une forme mtaboliquement active

Keep a symptom diary documenting stool frequency, consistency (using the Bristol Stool Chart), timing relative to injections and meals, and dietary intake

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Insufficient solvent causes opposite problems with concentrated solutions

If sleep disturbance occurs with evening dosing, switching to morning may help