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All generated bins were combined and dereplicated to yield a non-redundant set of MAGs using dRep v3.2.2 (parameters: -comp 50 -con 10 --P_ani 0.9 --S_ani 0.98) 115 at 98% average nucleotide identities

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381 Surprisingly, statins can decrease the levels of mevalonate-5-phosphate and prevent mutated p53 from binding to HSPs, thus promoting the degradation of structural p53 mutants by MDM2 or CHIP E3