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Protocol registration The protocol of this study was not registered

Mechanism: Semaglutide works primarily through appetite suppression by acting on GLP-1 receptors in the brain and gut

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One important limitation: the clinical weight loss results were modest

Unexplained hypercobalaminemia, particularly levels above 1,000 pg/mL, has been associated with liver disease, kidney dysfunction, myeloproliferative disorders, and certain solid cancers in multiple large-scale studies

This combination medicine belongs to a class of nutritional supplements