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The cormorbidities often associated with HFpEF such as obesity, diabetes mellitus, and hypertension as well as the metabolic changes associated with them are known to induce a state of inflammation that affects cardiac metabolism, as well as coronary vascular injury and ischemia [5]
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Sudano MJ, Mattos MCC, Fernandes CB, Mazieiro RR, Landim-Alvarenga FC
10.1016/j.ejphar.2019.01.030 65 SeverM.KlicekR.RadicB.BrcicL.ZoricicI.DrmicD.et al (2009)
30,109 Under nutrient excess, suppressed SIRT1 expression impairs autophagic activity, 96 leading to mitochondrial dysfunction and ROS accumulation, further disrupting insulin signaling
Compared with metformin, hazard ratios for colorectal and gallbladder cancers remained below one, but the differences were not statistically significant (Figure 3)
Structural insights into ISRIB, a memory-enhancing inhibitor of the integrated stress response
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