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Previously, the only evidenced and effective long-term treatment for obesity was weight-loss surgery where we have evidence that surgery is capable of giving long-term weight loss for 20 years or so
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98 One approach involves the autoregulated overexpression of key cell cycle regulators, 99,100 including CDK1, CDK4, CCNB1, and CCND1, which have been shown to induce 1520% proliferation of mature cardiomyocytes and improve post-MI outcomes
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As science and technology advance, pharmaceutical development has become more demanding than ever
