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NICE recommend tirzepatide and semaglutide for patients with at least one weight-related comorbidity and a BMI 35 kg/m 2 (or BMI 30 kg/m 2 and who meet the criteria for referral to specialist weight management services, for semaglutide only) and liraglutide for patients with a BMI 35 kg/m 2 , non-diabetic hyperglycaemia, and a high risk of cardiovascular disease
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Medication-specific factors require consideration of pharmacokinetic properties, with weekly formulations potentially having more prolonged effects than daily preparations [51]
Confirm that semaglutide (or tirzepatide) base, not semaglutide (or tirzepatide) salt, is used in the compounding process
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