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The combination is generally well-tolerated, but potential side effects include fatigue, headache, or dizziness from Zofran, alongside semaglutide-related effects like nausea, diarrhea, or reduced appetite

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White WB, Bakris GL, Bergenstal RM, Cannon CP, Cushman WC, Fleck P, Heller S, Mehta C, Nissen SE, Perez A, Wilson C, Zannad F