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This is due to concerns that the peptides proliferative effects could accelerate disease progression
Chronic ICV administration of oxyntomodulin, a GLP-1R agonist, in mice decreased body weight despite having no significant effects on food intake (Lockie et al., 2012)
[Abstract]2026 Jul 15:366:121670
A note on intermittent fasting and semaglutide (or tirzepatide): combining a restricted eating window with GLP-1 appetite suppression can make it harder to meet your protein, fiber, and overall nutrition needs
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