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Despite the flexibility within the N-terminal two residues, Glu3 of exendin-4 formed very similar contacts to that of Glu9 of GLP-1, however, interactions with residues residing at the base of the pocket were more transient for exendin-4 (7580% of the MD frames) than for GLP-1 in the MD simulations (97% of frames for Y152 1.47 and 100% for R190 2.60 ) (Supplementary Table 3)
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Besides affecting almost every tissue and organ, growth hormone promotes physical growth and normal metabolism.15 16 Its metabolic effects relate to its ability to stimulate the production of yet another hormone, insulin-like growth factor-1 (IGF-1)
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