2025;48(3):e48
G.RoedererM.AndersonM.GreenA.et al (2000)
The HECT domain-containing ubiquitin E3 ligase HUWE1, as a negative regulator of ferroptosis, specifically targets the transferrin receptor 1 (TfR1) for ubiquitination and proteasomal degradation, regulating iron metabolism, counteracting abnormal iron accumulation, inhibiting ferroptosis, and potentially mitigating acute liver injury caused by ischemia-reperfusion (I/R)[80]
Progressive loss of synaptic integrity in human apoE4 targeted replacement mice and attenuation by apoE2
As a widely used antihypertensive drug, losartan enhances vascular perfusion, thereby enhancing drug delivery and intratumoral invasion of immune effector cells and, on the other hand, enhances chemotherapy sensitivity by inhibiting IGF-1 signaling to reshape ovarian cancer and the microenvironment (140)
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