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In addition, the high expression of NRF2 enhances the expression of downstream SOD1, an important antioxidant enzyme that plays a crucial role in protecting cells from oxidative damage [36]

Together, they create a more powerful metabolic effect than either receptor alone, which explains why tirzepatide outperforms semaglutide in clinical comparisons

It is proposed that such a disruption of BBB permeability produces a vicious circle in which incremental reductions in cerebral perfusion accelerates the neurodegenerative process thus facilitating further drops in cerebral perfusion [11,26,27]

It has shown remarkable stability in experiments, as seen in the Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract study by Sikiri et al