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ICAM-1, intercellular adhesion molecule-1

This article reviews the distinct miRNAs that orchestrate PD pathogenesis by disrupting mitochondrial homeostasis, lysosomal clearance pathways, ferroptosis regulation, and neuroinflammatory responses

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The researchers identified PEN2 as a metformin binding partner that forms a complex with ATP6AP1, leading to AMPK activation through inhibition of the lysosomal v-ATPase

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