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Patient Safety Continuing appetite-suppressing medication at very low BMIs may increase the risk of: Excessive or unintended weight loss Nutritional deficiencies Lean muscle loss Hormonal disruption Disordered eating patterns The BMI 22 kg/m threshold acts as a safety boundary

Calcitonin receptor activation by amylin agonists raises a theoretical concern about bone turnover (calcitonin inhibits osteoclast activity)

For example, anti-epileptic drugs (AEDs) change the chemicals in the brain to stop seizures, but they do not cure epilepsy

The medication is not FDA-approved for weight loss

Because it works upstream, your body's natural feedback systems stay active