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Age-dependent upregulation of p53 and cytochrome c release and susceptibility to apoptosis in skeletal muscle fiber of aged rats: role of carnitine and lipoic acid

Thats rare

After pre-conditioning in the presence or absence of 50 nM Exendin-4 for additional 18 hours, culture medium was changed to serum-free DMEM containing 1 mM sodium pyruvate, without glucose and sodium bicarbonate

It shuttles long-chain fatty acids across the mitochondrial membrane where they are oxidized (burned) to produce ATP - the body's energy currency

These effects are more pronounced during the first few weeks and often improve as the patient adapts to the medication

Experiments (in triplicate) were completed by control reactions in the absence of substrate