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Additional work in this area is warranted to further evaluate the effect of glucagon-like peptide-1 receptor agonist (GLP1Ra) use on skeletal health outcomes in older adults, given the pilot nature of the trial, the small degree of weight loss achieved, and the well-described association between weight loss and fracture risk

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A smaller portion of extracellular glutamate is reabsorbed by presynaptic or postsynaptic neurons

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When administered directly into the cerebrospinal fluid of mice, it showed dose-dependent pain-relieving effects that were blocked by naloxone, confirming involvement of opioid pathways

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