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In BV2 and N2a cells treated with amyloid (A), berberine promotes cell proliferation, inhibits the activity of caspase-3, and reduces the rate of apoptosis, in addition, berberine promotes cell viability via the microRNA (miR)-188/nitric oxide synthase 1 (NOS1) pathway (Ye et al., 2009

So the way it does this is by activating a gene called UCP-1, uncoupling protein 1, norepinephrine is upstream of that, activating it

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Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione