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Key considerations include: The medication may have reduced potency, compromising diabetes management Chemical breakdown may alter the formulation Using medication beyond its expiry date is outside the licensed use The manufacturer cannot guarantee effectiveness after this date If you have used expired Trulicity, monitor your blood glucose levels closely and contact your GP or diabetes specialist nurse for guidance

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More commonly used medications in the treatment of Type 2 DM include: Biguanide Dipeptidyl peptidase 4 (DPP-4) inhibitors Glucagon-like peptide 1 (GLP-1) receptor agonists Dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonists Sodium-glucose cotransporter 2 (SGLT2) inhibitors Sulfonylureas Thiazolidinediones (TZDs) Biguanide The first and most foundational medication in type 2 diabetes management is metformin , the only drug in the biguanide class

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We considered an absolute reduction of 5.2% in TPV (20% of 26% reduction observed with atorvastatin) to be both plausible and minimally clinically important