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National Academy Press, 1989

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Efficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled on metformin: a 24-week, randomized, open-label, active-controlled study (GetGoal-X)

Lower doses may produce more subtle metabolic improvements, while higher doses tend to produce more dramatic changes across all measured parameters

As with similar compounds, side effects are still being studied