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Multiple new therapies are currently being evaluated as well, including oral medications and tirzepatide, the main ingredient in weight loss and type 2 diabetes medications Zepbound and Mounjaro
To determine, firstly, whether mean metabolite component scores in patients with stable schizophrenia differ from mean scores in healthy controls, and secondly, whether this difference is significantly leveraged by the sub-group of patients with residual schizophrenia, we regressed each component score in turn on two participant variables using a hierarchical regression model
Effects of folic acid supplementation on inflammatory markers: a grade-assessed systematic review and dose-response meta-analysis of randomized controlled trials
Endocrine Journal 2021;68(6):739-742
Response variability is significant: some individuals see rapid results while others require dose adjustments or alternative approaches
If applied locally via injection, as was done in the study, there is also a risk of structural damage as the needle could break the fragile external walls that protect the discs
