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Circumstances where stopping may be appropriate include intolerable side effects (such as persistent nausea or gastrointestinal symptoms), pregnancy or planning pregnancy, development of contraindications, or achievement of diabetes remission through significant lifestyle changes

A close look at the research into PT-141 for sexual function shows a noteworthy gap between 2007 and 2019

Teva (and other manufacturers) maintained exclusivity through the shift from chlorofluorocarbon (CFC) propellants to hydrofluoroalkane (HFA) propellants a formulation change mandated by the Montreal Protocol that required new NDAs and created new patent opportunities for the HFA formulation

Marcinkiewicz et al., 2002

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