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Mechanistic evidence has indicated that GLP-1RAs promote bone marrow-derived macrophage polarization into the M2 phenotype via the cAMP-PKA-signal transducers and activators of the transcription 3 (STAT3) pathway [137, 138]
And then there is the potential for side effects
Hepatitis/Elevated liver enzymes/Jaundice Diabetic retinopathy problems: Changes in vision in those with type II diabetes, particularly vision problems may worsen in those with a history of diabetic retinopathy Severe gastrointestinal disease: May cause gastrointestinal disease
Yoshii Y, Furukawa T, Waki A, Okuyama H, Inoue M, Itoh M, et al
Even the most expensive compounded tirzepatide through Elevate Health, at $499 per month, represents a fraction of the brand-name cost
