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After one-third of the study participants have been enrolled and completed follow-up, the DSMBs will review the data and make recommendations concerning continuation, modification or termination of the study due to unexpectedly large beneficial effects or serious side effects and can suggest extension of the trial should the primary outcomes occur less often than anticipated

Injection : A small, quick injection is given in the muscle, typically in the upper arm or thigh

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The Mechanism: The Hyperexcitable Brain The migraine brain is genetically distinct

Doctors are quick to say "research says" or "guidance says" without quoting the specific research or guidance