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In addition, improved glucose control in T2DM would be expected to include improved metabolic effects, including limited insulin signaling, which could be an alternative mechanism wherein GLP-1 RAs indirectly affect the brain

[Updated 2020 Jun 18]

For example, enteric neurons express glutamate transporters and are in close proximity to VANs expressing glutamate-sensitive receptors 75

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The reduction of NO also results in the formation of another RNS identified as the nitroxyl anion (NO )