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Together, these coordinated actions provide a mechanistic explanation for the renal protective effects of SGLT2 inhibitors in DKD and offer a strong biological basis for their clinical application in the treatment of ferroptosis-related kidney injury

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But if its almost time for your next dose, double up the next day because the life of the medication is long in the body, notes the ATA

The catalytic activity of the molecule appears to be involved in at least some of these actions, and several endogenous substrates have been identified, although a role for protease-independent functions related to metabolic homeostasis has also been suggested

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