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Considering the latter possibility, treatments that were considered failures in previous clinical trials could be reanalyzed for potential efficacy in ALS, taking into account the duration of the disease at the start of therapy. Therefore, using diagnostic criteria that enables earlier identification of the disease and a change in the physicians attitude towards offering an early diagnosis and treatment could result in better ALS patient outcomes.

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Efficacy and Safety of Mecobalamin on Peripheral Neuropathy PubMed / systematic review article: Concludes that mecobalamin (alone or combined) may improve clinical outcomes and nerve conduction in peripheral neuropathy

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One of the factors that spurs the progression of liver disease is that a protein called Bcl-xl begins to malfunction, failing to control the release of a second protein called cytochrome C, which occurs when a liver cell dies