The first scaffold is a tertiary amine that acquires a positive charge in response to an acidic component in endosomes and lysosomes that promotes membrane destabilization and subsequent endosomal escape
This presents a meaningful clinical concern, particularly in populations exposed to polypharmacy or managing complex comorbidities
Afrin LB, Butterfield JH, Raithel M, et al
No claims are made regarding therapeutic, diagnostic, or biological suitability beyond research use
10.2174/1381612824666180614082950 34 KlicekR.KolencD.SuranJ.DrmicD.BrcicL.AralicaG.et al (2013)
Researchers also distinguish reduced glutathione (GSH) from the disulfide GSSG, since it is the GSSG/2GSH ratio, not total glutathione, that Schafer and Buettner (Free Radical Biology and Medicine, 2001) established as the quantitative index of the cellular redox environment