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The FDA's period of enforcement discretion regarding certain compounded GLP-1 preparations the accommodation created while the approved products were in shortage ended in 2025, on staged dates in February and March for tirzepatide and April and May for semaglutide

Point estimates are represented as circles, and horizontal bars indicate 95% confidence intervals

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The expiration date reflects the guaranteed stability window

taking semaglutide with food, staying hydrated, and eating smaller meals can minimize gastrointestinal upset