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The change in G protein signaling in persistently depolarized cells may be of therapeutic and pathophysiological significance, as it explains how the insulinotropic effect of GLP-1 is maintained in T2D, but that of GIP is lost
Neuropharmacology , 146, 298309.
Importantly, despite the evidence for use of SGLT-2 inhibitors for DKD treatment, they should not be used in patients with type 1 diabetes because of the risk of euglycaemic diabetic ketoacidosis
the weight loss indication is also undergoing internal evaluation
It is expressed in both central and peripheral tissues and has been implicated in the regulation of food intake, lipid metabolism, and body weight (Lv et al., 2019)
OrdovasJMFergusonLRTaiESMathersJC.Personalised nutrition and health
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