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Limited RCTs have been published thus far on patient populations with hypertension specifically, with blood pressure variations being measured as a primary endpoint and tracked long-term

Thompson, D

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An important nuance from the NEJM paper: The paper notes that the mechanism "may further amplify heart rate elevation" through the glucagon receptor, while acknowledging this is consistent with the known pharmacology rather than proven in direct mechanistic studies specific to retatrutide

Advances in Therapy, 39 (6), 2452-2467