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Background information was taken from Cleveland Clinic, GoodRX, the health research group KFF and The Associated Press

Other Common Side Effects of Semaglutide In addition to fatigue, semaglutide has other potential side effects

"Anticoagulants and transaminase elevation"

Do not use tirzepatide if you: Have a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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"SURMOUNT-5: Greater Loss of Weight, Waist Circumference With Tirzepatide Than Semaglutide." July 2025