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Thirty-two male mice were started on a 60% high-fat diet of 5.24 kcal/g at three weeks of age for 19 weeks, followed by a 45% HFD of 4.73 kcal/g for six additional weeks

174 Research also suggests tribulus may not alter testosterone levels in men younger than 40 years old

The most commonly reported side effects for both agents are gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, particularly during dose escalation

PMID: 15664732

Research published in Molecular Medicine demonstrates that ARA-290 reduces TNF-alpha, IL-6, and IL-1beta in damaged tissue without immune suppression in healthy tissue

Much of the published work on it comes from animal and lab studies, not from large human trials