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This peripheral mechanism complements central appetite suppression

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As of the time of writing, retatrutide has not received marketing authorisation in the United Kingdom

It is a combination of a GLP-1 agonist and an amylin agonist, explains Richard Siegel, MD, co-director of the Diabetes and Lipid Center at Tufts Medical Center and endocrinologist at Tufts Medicine Weight & Wellness Center Stoneham

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But physiology is foundational